R. Kelly faces a bail hearing on Tuesday over federal charges that he ran a racketeering scheme trafficking women and girls for sex.
Reuters reports the indictments unsealed in Brooklyn, New York, and Chicago on Friday.
The prosecutors said Kelly forcibly kept people under his control and then intimidated witnesses and bought their silence.
Kelly is already charged with sexual assault in Illinois.
He was taken into custody by New York City police detectives and federal agents on Thursday in Chicago.