German Chancellor Angela Merkel warned that the chances for an orderly Brexit are narrowing, while speaking at a press conference alongside Laos Prime Minister Thongloun Sisoulith in Berlin on Wednesday.

The comments come after UK Prime Minister Theresa May suffered another defeat in the House of Commons on Tuesday, with MPs rejecting her revised plan for a withdrawal agreement.

"We have not given up the goal of an orderly exit (for Britain) but yesterday's events mean the options have become narrower", Merkel said, adding she regretted the UK Parliament's decision to reject the deal.

The Chancellor added that the results of the next vote in Westminster will determine which "direction" to consider.

She also mentioned the backstop issue, stressing that Ireland will be particularly affected if there is no agreed upon solution.

On Wednesday, British MPs are voting on whether UK will leave the EU with no deal, while on Thursday they are conducting a vote regarding the extension of Article 50.

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