Thirty-five people were hurt in a 63-vehicle, chain-reaction crash in Virginia on Sunday.
Reuters reports the incident took place on a foggy and icy stretch of highway early Sunday morning.
Authorities are working at the scene of the pileup, which began shortly before 8 a.m.
All westbound lanes of Interstate 64 in York County, Virginia remained closed Sunday afternoon.
The police tweeted injuries ranged from minor to life-threatening.
Video footage of the scene showed a sea of cars that had collided with one another or the interstate barricade.