Two people were killed and 35 hospitalized after a train partially derailed in Chester, Pennsylvania, broadcaster ABC reported Sunday citing the local fire department.
Amtrak - the company that operates the train, which was carrying 341 people - did not confirm the casualties but said the train had derailed after hitting a backhoe on the track.
ABC said that the identities of the two victims had yet to be confirmed and that 35 other people were receiving treatment in hospital for non-life-threatening injuries.
It was unclear how many others were injured but not yet hospitalized.
The train had been travelling from New York to Savannah, Georgia, when it came off the track in Chester, a town south-west of Philadelphia.
Amtrak said it was suspending its service between Wilmington and Philadelphia.