At least nine people were killed and 52 injured when a magnitude-5.3 earthquake jolted southern Peru late Sunday, officials said.
The quake was centred near the town of Chivay, in the Arequipa region, and struck at a depth of 8 kilometres, the National Civil Defence Institute said Monday.
At least 120 homes were destroyed, the state agency said.
Prime Minister Fernando Zavala said a state of emergency would be declared for affected areas. Three helicopters have been sent to rescue people trapped in remote villages.
Among the dead was a 66-year-old US citizen staying at a hotel near Colca Canyon, a popular hiking destination.
A magnitude-7.9 earthquake hit Pisco Province in 2007, killing nearly 600 people. In 2001, a magnitude-8.4 temblor killed 240 in Arequipa.