Inter Milan were held 1-1 at home to Bologna Sunday while Roma lost 3-1 at Torino despite Francesco Totti's 250th Serie A goal.
Ivan Perisic levelled an opener from Bologna striker Mattia Destro, but the Nerazzurri failed to get a winner despite their constant pressing, with Eder and new arrival Gabriel coming on after the break alongside striker Mauro Icardi.
Destro fired a low shot past Samir Handanovic in the 14th minute at the Guiseppe Meazza after Simone Verdi stormed past two defenders to set him up.
Perisic struck on 37, volleying from a left angle into the far corner off Antonio Candreva. Inter fought in vain for the winner, moving to third place but slipping four points from leaders Juventus.
"It’s not our best performance, but we fought until the end and kept looking for the win, which tired us out," Inter boss Frank de Boer said. "I’m quite satisfied with how we played, but I would like to see us control the whole match.”
In Turin, Iago Falque's brace helped Torino defeat Roma in a pulsating game in which Totti's milestone goal two days before his 40th birthday was to no avail.
Andrea Belotti nodded his fifth goal of the season on eight minutes to open the scoring at the Stadio Olimpico. Fellow striker Falque hit the right post but did better in the 53rd by converting a penalty after Bruno Peres brought down Belotti.
Totti pulled one back in the 55th from the spot but Falque secured the hosts' victory with a deflected drive 10 minutes later.
“Unfortunately our history says that we cannot maintain the pace needed in tackles, in running in the efforts to help a team-mate,” Roma coach Luciano Spalletti said.
“We have too many ups-and-downs and this must be addressed during the week, and it is my duty to do it.”
Roma stayed on 10 points from six games, level with Bologna, Chievo, Lazio and AC Milan, after their late scoreless draw at Fiorentina. Inter sit on 11 and Torino are on eight with Genoa and Fiorentina.
Champions Juventus won 1-0 at Palermo on Saturday to stay top on 15 points. Napoli trail on 14 after beating Chievo 2-0.
Elsewhere on Sunday, a Keita Balde firm drive and a late header from Senad Lulic secured Lazio's 2-0 win against Empoli. Sassuolo won 1-0 against Udinese from Gregoire Defrel.
Nine-man Genoa drew 1-1 at home to Pescara.
Giovanni Simeone, the son of Atletico Madrid coach Diego, scored for the hosts in the 47th minute, controlling and shooting low into the left corner. But Edenilson and Goran Pandev were sent off 16 and 11 minutes from time, respectively, and Pescara levelled in the 85th from Rey Manaj.
Two more games complete the sixth round Monday.