Finland striker Joel Pohjanpalo came off the bench to score a late hat-trick as Bayer Leverkusen beat SV Hamburg 3-1, while Borussia Dortmund slipped to a 1-0 defeat at newly-promoted RB Leipzig in the German football Bundesliga on Saturday.
Hertha Berlin meanwhile made it two straight wins with a 2-0 victory at Ingolstadt, promoted Freiburg came from behind to beat Borussia Moenchengladbach 3-1, Wolfsburg were held to a goalless draw by Cologne, and Darmstadt snatched a late 1-0 victory over Eintracht Frankfurt.
Hertha's win put them level on six points after two matches with leaders Bayern Munich, who won 2-0 at Schalke on Friday.
Borussia Dortmund stay on 3 points after going down to a late goal at RB Leipzig, who earned their first Bundesliga win before 42,558 fans on their home debut in the top flight.
It was a tale of two substitutes and two new signings for Leipzig, with Guinea international Naby Keita coming off the bench in the 84th minute to net into the roof of the net from close range four minutes later after taking a pass from Scotland's Oliver Burke.
Nineteen-year-old Burke had come on in the 69th minute for his debut after joining the club from Nottingham Forest a few days before the close of the transfer deadline.
Sports director Ralf Rangnick said: "When the goal went in you had the feeling the (stadium) roof would blow off. This is great for the city, for the club, simply fantastic."
The match was boycotted by a Dortmund fan group objecting to the use of the Leipzig club as a marketing vehicle by energy drinks firm Red Bull.
The Dortmund fans who did make their way to Leipzig saw Mario Goetze make his debut following his return to the club from Bayern Munich. The Germany international was often involved before coming off after 70 minutes, while new signing Andre Schuerrle was a lively presence, skimming the top of the bar with Dortmund's best effort late in the game before the home side secured a famous victory.
Hamburg summer signing Bobby Wood put the visitors ahead at Leverkusen when he was sent clear on goal in the 58th minute and was able to finish when keeper Bernd Leno came out of goal but missed his intended interception.
But it was Leverkusen's own pre-season newcomer Pohjanpalo who turned the game around after coming off the bench in the 72nd minute.
The 21-year-old striker signed from Fortuna Dusseldorf headed the home side level in the 80th minute and then in stoppage time struck with a first-time shot for his second and finished clinically for his hat-trick.
"They were three picture book goals," Leverkusen coach Roger Schmidt said.
In Ingolstadt, striker Vedad Ibisevic scored with a left-foot finish in the eighth minute and Julian Schieber headed the second four minutes from time to give Hertha the points.
Freiburg meanwhile made it a club record seventh straight home win with three second-half goals against Gladbach.
The visitors took the lead through Thorgan Hazard's curled shot from the edge of the area in the 35th minute. But the home side were rewarded for increased pressure when Maximilian Philipp fired in from the edge of the area in the 54th. Philipp added a second in the 85th and Nils Peterson converted a penalty three minutes later.
"I was very surprised the boys kept that up for 90 minutes," Freiburg coach Christian Streich said. "We've set the bar high and now we have to measure up against it."
Germany striker Mario Gomez made his debut for Wolfsburg but was unable to break the deadlock in a goalless draw against visiting Cologne.
Darmstadt and Frankfurt were also heading for a goalless encounter until Sandro Sirigu's intended cross went sailed into goal in the last minute to give the home side the points.