Novak Djokovic pulled ahead in the ATP season win column, earning his 25th victory with a 6-3, 6-4 defeat of Austrian talent Dominic Thiem to reach the quarter-finals of the Miami Masters on Tuesday.
The win nudges the top seed one ahead of Thiem, who also came into their match with a leading 24 wins since the start of the year.
The victory gave the runaway world number one victories in 27 of his last 28 Miami matches dating to 2011, running his record 2016 to 25-1.
Thiem, at age 22 the youngest in the top 20, was denied his second straight Miami quarter-final and lost for the tenth time on hardcourts to a top 10 opponent.
Djokovic was bothered by nine double-faults but saved 14 or the 15 break points he faced in a contest lasting just under two hours.
The winner called the match "far from easy, I struggled a lot."
Thiem had hopes to better use his break opportunities. "With only one of 15 break points, you cannot beat anyone - for sure, not Djokovic."
Former finalist and seventh seed Tomas Berdych overcame French 10th seed Richard Gasquet 6-4, 3-6, 7-5.
Canadian 12th seed Milos Raonic reached a Masters quarter-final for the second week in a row after an injury comeback this season, hammering Bosnian Damir Dzumhur 6-0, 6-3.
Belgian David Goffin, the number 15, put out Argentine Horacio Zeballos 7-5, 6-3 while Gilles Simon won an all-French battle 6-0, 6-1 over Lucas Pouille.
Nick Kyrgios became the first Australian into the Miami quarters since Lleyton Hewitt in 2002 thanks to a defeat of Russian Andrey Kuznetsov 7-6 (7-3), 6-3.
Kyrgios took 83 minutes claim victory with 11 aces and 24 winners.
In the women's draw, Switzerland's Timea Bacsinszky toppled her second top five opponent in as many days on Tuesday, eliminating fifth seed Simona Halep 4-6, 6-3, 6-2 to reach the semi-finals.
Bacsinszky, ranked 20th, added Romanian Halep to her victim list this week which began 24 hours earlier with a defeat of third seed Agnieszka Radwanska.
The Roland Garros semi-finalist finished off a comeback lasting two and a half hours on the first of three match points as she drilled a backhand winner past Halep.
"I came back from a long road," Bacsinszky said. "It was a tough fight.
"It gives me a big confidence to have these two wins, but it doesn't change that I'm going to have a fierce opponent and it's going to be tough.
"I just hope I'm going to be able to play well and be efficient in the next match. Hopefully I win the last point. If not, then it's okay. I'll try for the next tournament."
Bacsinszky finished her see-saw battle with breaks on five of nine chances, striking 20 winners and 43 unforced errors.
She play 15th seed Svetlana Kuznetsova, who beat fellow Russian Ekaterina Makarova 6-7 (3-7), 6-4, 6-3.