SpaceX's Dragon capsule plunked Sunday into the Pacific Ocean, hours after separating from the International Space Station, the commercial space company announced.
"Recovery teams en route to Dragon," SpaceX tweeted.
The company said that a "good splashdown" was confirmed for the unmanned spacecraft, which was carrying science and research cargo for US space agency NASA from the orbiting space station.
NASA said early Sunday that a robotic arm on the station had released the Dragon with 2.45 tons of cargo, mostly samples for biological research.
After Dragon was released, the spacecraft made three departure burns to steer away from the space station, jettisoned its trunk, conducted a larger burn to drop out of orbit and deployed small parachutes, before opening its three main chutes in the final minutes prior to splashdown.
The mission, for which the capsule docked with the station on February 19, was the 10th using a SpaceX capsule. The company has a contract to begin carrying astronauts into orbit using Dragon spacecraft by 2020.
The Dragon launch last month was the first by a commercial rocket from Complex 39A at NASA's Kennedy Space Centre. The same launch pad hosted the Apollo moon missions and space shuttle launches.
SpaceX was founded by technology entrepreneur Elon Musk, chairman of Tesla.